Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD‐ADSP): A global effort to identify genetic factors in Alzheimer's disease.
Résumé
INTRODUCTION Alzheimer's disease (AD) remains a major neurocognitive disorder of global health significance. Globalizing ancestral diversity in AD genetics is essential to identify causal variants, improve diagnosis, and enable equitable therapeutic interventions across populations. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD‐ADSP) initiative addresses this by including African ancestry and Hispanic/Latinx (HL) ancestry populations. METHODS READD‐ADSP, a case–control study, aims to recruit, evaluate, and retain 13,000 participants: 5000 Indigenous Africans, 4000 African Americans, and 4000 Hispanic/Latinix individuals. In Africa, recruitment involves nine sub‐Saharan African countries under the African Dementia Consortium, and with protocols ensuring standardized data collection, phenotype harmonization, culturally informed diagnostic algorithms, and robust community engagement. RESULTS Study pparticipants are recruited, ascertained and retained. Blood samples and fractions (DNA, plasma, RNA) are biobanked for genomic, epigenomic, proteomic, and transcriptomic analyses. DISCUSSION This study will advance precision ADRD medicine and establish a model for working with diverse global cohorts of brain disorders. Highlights Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD‐ADSP) addresses critical gaps in Alzheimer's Disease and Related Dementias (ADRD) research by including underrepresented groups. The study recruits 13,000 participants of African, African American, and Hispanic/Latinx ancestries. Standardized protocols enable rigorous phenotyping and harmonization across diverse populations. Findings will inform precision medicine and reduce health disparities in ADRD outcomes.
Mots clés
- precision medicine Highlights Standardized protocols enable
- Hispanic/Latinx ancestry
- global diversity
- Alzheimer's disease and related dementias
- African ancestry
- African ancestry Alzheimer's disease and related dementias global diversity Hispanic/Latinx ancestry precision medicine Highlights Standardized protocols enable
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