Chikungunya and Zika Viruses : Co-Circulation and the Interplay between Viral Proteins and Host Factors - IRD - Institut de recherche pour le développement Access content directly
Journal Articles Pathogens Year : 2021

Chikungunya and Zika Viruses : Co-Circulation and the Interplay between Viral Proteins and Host Factors

Sineewanlaya Wichit
Nuttamonpat Gumpangseth
  • Function : Author
Sakda Yainoy
Siwaret Arikit
  • Function : Author
  • PersonId : 1130426
Chuchard Punsawad
  • Function : Author
  • PersonId : 1141234

Abstract

Chikungunya and Zika viruses, both transmitted by mosquito vectors, have globally re-emerged over for the last 60 years and resulted in crucial social and economic concerns. Presently, there is no specific antiviral agent or vaccine against these debilitating viruses. Understanding viral–host interactions is needed to develop targeted therapeutics. However, there is presently limited information in this area. In this review, we start with the updated virology and replication cycle of each virus. Transmission by similar mosquito vectors, frequent co-circulation, and occurrence of co-infection are summarized. Finally, the targeted host proteins/factors used by the viruses are discussed. There is an urgent need to better understand the virus–host interactions that will facilitate antiviral drug development and thus reduce the global burden of infections caused by arboviruses.
Fichier principal
Vignette du fichier
DMissé_Papier Chikungunya Pathogens.pdf (1.61 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

ird-03610048 , version 1 (16-03-2022)

Identifiers

Cite

Sineewanlaya Wichit, Nuttamonpat Gumpangseth, Rodolphe Hamel, Sakda Yainoy, Siwaret Arikit, et al.. Chikungunya and Zika Viruses : Co-Circulation and the Interplay between Viral Proteins and Host Factors. Pathogens, 2021, 10 (4), pp.448. ⟨10.3390/pathogens10040448⟩. ⟨ird-03610048⟩
20 View
93 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More