Biological activities of triterpenoids from Poraqueiba sericea stems - IRD - Institut de recherche pour le développement Access content directly
Journal Articles Natural Product Research Year : 2017

Biological activities of triterpenoids from Poraqueiba sericea stems


Eleven compounds were isolated from Poraqueiba sericea stems and identified as niga-ichigoside-F1 (1), trachelosperoside B1 (2), 4-epi-niga-ichigoside (7), 19α-hydroxyasiatic acid (3), myrianthic acid (4), hyptatic acid (5), trachelosperogenin B (6), arjunolic acid (8), and trachelosperogenin E (9), secologanoside (10) and secoxyloganin (11). Compounds 1–11 were tested for their antileishmanial activities against Leishmania infantum promastigotes, 1–6 and 8–11 were tested for their cytotoxic activities on fibroblasts, 1–3, 5–6, 8–11 were evaluated for their anti-elastase and anti-acetylcholinesterase assays activities by a spectrophotometric method and 1–2, 5 and 7–10 were tested using bioautography for their β-glucosidase. No antileishmanial activity was detected; compounds 1, 2 and 11 showed a moderate cytotoxic activity with IC 50 17.7, 20.5 and 10.9 μg/mL, respectively; compounds 2, 8, 9 and 10 gave a percentage of inhibition ranging from 13 to 16% (at 50 μg/mL) and compounds 1 and 2 showed an inhibition zone on β-glucosidase and anti-acetylcholinesterase assays.
Fichier principal
Vignette du fichier
GNPL_A_1241998 - PROOF.pdf (407.67 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

ird-01382564 , version 1 (17-10-2016)



Ilhem Zebiri, Mohamed Haddad, Laurent Duca, Michel Sauvain, Lucie Paloque, et al.. Biological activities of triterpenoids from Poraqueiba sericea stems. Natural Product Research, 2017, 31 (11), pp.1333-1338. ⟨10.1080/14786419.2016.1241998⟩. ⟨ird-01382564⟩
223 View
566 Download



Gmail Mastodon Facebook X LinkedIn More