A new phthalide derivative from Peperomia nivalis - IRD - Institut de recherche pour le développement Access content directly
Journal Articles Natural Product Research Year : 2017

A new phthalide derivative from Peperomia nivalis


One new phthalide (1) was isolated from aerial parts of Peperomia nivalis, along with known compounds (2 and 3), reported in this species for the first time. The structure of the new compound was characterised on the basis of 1D (1 H and 13 C NMR), 2D (COSY, HMQC, HMBC and NOESY) NMR and high-resolution mass spectral (HRMS) data. Compound 2 was isolated from a natural source for the first time but previously synthesised. Compounds 1–3 were evaluated for their anti-Helicobacter pylori and anti-Plasmodium falciparum activities. Compound 1 showed moderate activities against H. pylori (MIC 47.5 μM) and the F32-Tanzania strain of P. falciparum (IC 50 8.5 μM). Compounds 2 and 3 exhibited weak anti-H. pylori activity (MIC 241.3 and 237.6 μM, respectively) and were inactive against P. falciparum.
Fichier principal
Vignette du fichier
GNPL_A_1219857 - PROOF.pdf (410.26 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

ird-01381569 , version 1 (17-10-2016)



Pedro Vásquez-Ocmín, Mohamed Haddad, Alice Gadea, Valérie Jullian, Denis Castillo, et al.. A new phthalide derivative from Peperomia nivalis. Natural Product Research, 2017, 31 (2), pp.138-142. ⟨10.1080/14786419.2016.1219857⟩. ⟨ird-01381569⟩
99 View
505 Download



Gmail Facebook X LinkedIn More