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Article Dans Une Revue Journal of Supercritical Fluids Année : 2024

Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization

Clément Brandel
Yohann Cartigny

Résumé

We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO2 as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO2. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.

Domaines

Matériaux
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samedi 21 décembre 2024
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Dates et versions

hal-04630115 , version 1 (01-07-2024)

Identifiants

Citer

Joséphine de Meester, Patrick Layrisse, Mathieu Marchivie, Laurent Collard, Guillaume Wery, et al.. Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization. Journal of Supercritical Fluids, 2024, 212, pp.106339. ⟨10.1016/j.supflu.2024.106339⟩. ⟨hal-04630115⟩
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