Lifestyle and incident dementia: A COSMIC individual participant datameta-analysis.
Résumé
Abstract INTRODUCTION The LIfestyle for BRAin Health (LIBRA) index yields a dementia risk score based on modifiable lifestyle factors and is validated in Western samples. We investigated whether the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics. METHODS We combined data from 21 prospective cohorts across six continents ( N = 31,680) and conducted cohort‐specific Cox proportional hazard regression analyses in a two‐step individual participant data meta‐analysis. RESULTS A one‐standard‐deviation increase in LIBRA score was associated with a 21% higher risk for dementia. The association was stronger for Asian cohorts compared to European cohorts, and for individuals aged ≤75 years (vs older), though only within the first 5 years of follow‐up. No interactions with sex, education, or socioeconomic position were observed. DISCUSSION Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups. Highlights A two‐step individual participant data meta‐analysis was conducted. This was done at a global scale using data from 21 ethno‐regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.
Mots clés
age dementia dementia risk reduction education effect modification ethnicity individual participant data meta-analysis interaction lifestyle primary prevention region risk factor risk personalization sex socioeconomic Highlights
age
dementia
dementia risk reduction
education
effect modification
ethnicity
individual participant data meta-analysis
interaction
lifestyle
primary prevention
region
risk factor
risk personalization
sex
socioeconomic Highlights
Domaines
Santé publique et épidémiologie
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